Neurogenesis in Stroke Recovery
To gain a better understanding of adult neurogenesis in the pathological brain, our lab has numerous projects assessing the contribution of neural stem and progenitors cells in the brain following stroke. Ongoing work in the lab uses methods including transgenic mouse models, optogenetics and single cell RNA sequencing to better elucidate how endogenous stem cells in the brain can be used to promote recovery following stroke.
Autophagy and Neurogenesis
We still have only a very limited understanding of the mechanisms regulating adult neurogenesis. These studies provide an integrated, multi-level analysis that links the different main players involved in autophagy to the regulation of the different stages of adult neurogenesis, as well as changes in gene expression during this process.
Cortical Reorganization Post-Stroke
Non-invasive brain stimulation techniques are under clinical trials to enhance recovery following stroke. In order to advance the understanding of the endogenous repair and plasticity mechanisms underlying recovery, as well as determine the most optimal brain stimulation targets to improve recovery these studies determine: i) what cells are part of the network that is reconfigured during stroke recovery, and ii) when is the critical period during which these modifications should occur to promote recovery.